Clinical Case
BIOMES Framework for Limb Salvage and CLTI Triage
Clinical framework for identifying high-risk lower-extremity wounds across six domains to enable early specialist referral and limb salvage.
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Clinical Cases
Real-world wound care cases with documented outcomes and clinical insights.
Clinical Case
Bioactive Glass Fiber Matrix for Refractory VLUs — Veterans Case Series
Weekly borate bioactive glass fiber matrix rapidly reduced exudate and pain in two veterans with five refractory venous leg ulcers, enabling compression and healing in 4 of 5 wounds.
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Clinical Case
Acellular Fish Skin Bridge to STSG After Open TMA | Limb Salvage
Learn how acellular fish skin grafts create a granulating bridge in open transmetatarsal amputations, enabling STSG in ~3–6 weeks while preserving limb function.
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Clinical Case
NPWTi-d for Infected Abdominal Dehiscence After Surgery
Learn how NPWTi-d with hypochlorous acid accelerates cleansing, clears infection, and supports closure of large dehisced abdominal wounds after body-contouring surgery.
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Clinical Case
Hydromechanical Debridement With NPWTi-d for Limb Salvage
Learn how NPWTi-d with hypochlorous acid accelerates debridement, reduces bioburden, and supports limb salvage in complex diabetic lower-extremity wounds.
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Clinical Case
Bioactive Glass Matrix for Pressure Injuries: Early PAR & Closure
Three chronic pressure injuries achieved 71–84% week-one area reduction using borate-based bioactive glass fiber matrix with closure within months.
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Clinical Case
Bioactive Glass Matrix for Complex Leg Wounds: 4-Case Series
Borate-based bioactive glass fibrous matrix shows substantial healing improvements in four refractory lower-extremity wounds, including complete DFU closure.
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Clinical Case
Bioactive Glass Matrix for Hydroxyurea Leg Ulcers
71-year-old polycythemia vera patient achieved rapid healing of three medication-induced ankle ulcers using weekly bioactive glass matrix applications.
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Clinical Case
Copper-Iodine Pocket Irrigation: 20-Patient Safety Study
Safety data on copper-iodine complex solution for breast implant pocket irrigation shows no adverse reactions in prospective 20-patient series.
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Clinical Case
Nonhealing 'Abscess' After I&D? Think Epidermoid Cyst (and Plan Excision)
Chronic post-drainage wounds may conceal epidermoid cysts. Complete capsule excision, not repeated drainage, offers definitive healing.
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Clinical Case
Continuous Topical Oxygen Therapy: 5 Real-World Cases
Five complex chronic wounds—surgical dehiscence, burns, osteoradionecrosis—achieved complete closure using continuous topical oxygen as adjunct.
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Clinical Case
Polycythemia Vera Leg Ulcer: Multimodal Case & Protocol
JAK inhibition and anti-biofilm care reversed an 83.5% area reduction in a chronic PV-associated leg ulcer after hydroxyurea discontinuation.
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Clinical Case
BBSM for Pressor Injuries: Safety, Timing & Outcomes
Synthetic bilayer dermal matrix shows promise in reconstructing foot tissue damaged by vasopressor-induced ischemia, enabling limb salvage without skin grafting.
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Clinical Case
Super Absorbent Dressings + Two-Layer Compression Heal Draining Leg Wounds
Advanced wound care protocol combining super-absorbent dressings, ORC/collagen/silver primary layers, and two-layer compression for exudative wounds.
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Clinical Case
Multilayer Compression Improves Skin Quality in CVI: 10-Patient Series
Case series examining how modern multilayer compression wraps with pressure indicators improve skin quality and comfort in CVI patients.
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Clinical Case
All-in-One NPWT Dressing for Complex Wounds: 3 Case Results
Case series examining all-in-one peel-and-place NPWT dressings with hybrid silicone-acrylic drapes for complex wounds and skin protection.
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Clinical Case
Borate Bioactive Glass Matrix for Stalled Wounds: When to Add It
Three medically complex stalled wounds achieved closure or significant area reduction after boron-based bioactive glass fiber matrix application.
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Clinical Case
Novel Repair for Recurrent Achilles Tendon Rupture
Bipedicled fasciocutaneous flap reconstruction offers a vessel-preserving alternative for chronic Achilles wounds when traditional repairs fail.
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Clinical Case
NPWTi-d in 30 Patients: Settings, Usability & Early Outcomes
A Malaysian wound-care unit evaluated NPWT with instillation in 30 patients, reporting rapid granulation, no adverse events, and frequent readiness for closure.
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Clinical Case
Massive Localized Lymphedema: Panniculectomy Resolves Chronic Wounds
Panniculectomy with advanced surgical techniques achieves durable wound closure and restored mobility in morbidly obese patients with MLL.
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Clinical Case
GV/MB PVA & PU Foams for ECF Wounds: Case-Based Protocol
Post-Whipple enterocutaneous fistula management using gentian violet-methylene blue foam dressings with documented healing over four months.
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Clinical Case
Fish Skin Grafts for Post-Radiation Calf Wounds: Limb Salvage Case Study
Acellular fish skin grafts with omega-3 fatty acids enabled limb salvage in a 93-year-old with radiation-damaged calf wound when conventional therapies failed.
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Clinical Case
Is Pure Hypochlorous Acid Safe in the NICU?
Retrospective review of 100+ NICU patients examining safety of pure hypochlorous acid wound cleanser in premature infants from 21-40 weeks gestation.
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Clinical Case
Seven-Day Peel-and-Place NPWT for Leg Wounds: Initial Clinical Experience
Initial 6-wound clinical series demonstrates encapsulated, peel-and-place NPWT dressing maintains seven-day seals with simplified application for leg wounds.
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Clinical Case
Urinary Bladder Matrix for HS Defects: Outpatient Healing Results
Case series shows how urinary bladder matrix (UBM) scaffolds enable outpatient management of large hidradenitis suppurativa excision wounds in young patients.
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Clinical Case
Filling Dead Space in Lower-Extremity Wounds with Fish Skin Grafts
Acellular fish skin grafts effectively fill residual voids in complex lower-extremity wounds post-debridement, supporting granulation and closure without complications.
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Clinical Case
Intact Fish Skin Grafts for Neonatal Wounds: Case Series
Early outcomes of intact fish-skin grafts for complex wounds in premature neonates, showing rapid closure with minimal adverse effects.
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Clinical Case
ESWT for Diabetic Foot Ulcers: Faster Healing With Broad-Focused Shockwaves
Evidence supports broad-focused extracorporeal shockwave therapy as a safe, noninvasive adjunct for stalled Wagner 1–3 diabetic foot ulcers.
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Clinical Case
ADM + NPWT for Open Fractures: 7-Case Series
Meshed HR-ADM combined with NPWT for extremity wounds with periosteal stripping achieves healthy granulation in all cases, 86% closure rates.
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Clinical Case
Bioactive Glass Matrix Heals Dorsal Foot Ulcer with Exposed Hardware
A 69-year-old achieved 88.9% wound closure using borate-based bioactive glass after hardware removal failed prior therapies.
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Clinical Case
Fish Skin Before STSG: Staged DFU Reconstruction
Two-stage surgical approach using acellular fish-skin graft followed by split-thickness skin graft for chronic diabetic foot ulcers.
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Clinical Case
Hydroxyurea-Associated Heel Ulcer in PV and Diabetes: ON101 Case
67-year-old with polycythemia vera on hydroxyurea and diabetes healed 9-month chronic heel ulcer in 14 days using ON101 topical cream.
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Clinical Case
Squamous Cell Carcinoma from Pilonidal Disease: Marjolin Ulcer Case
Clinical guide on recognizing squamous cell carcinoma transformation in pilonidal disease with case report and practical diagnostic workflow.
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Clinical Case
Single-Stage Wound Repair Using Human Reticular ADM
Case series of 5 trauma patients shows single-stage reconstruction with reticular acellular dermal matrix achieves durable closure in 2.5 months.
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Clinical Case
Peel-and-Place NPWT for Lower-Leg Wounds: 12-Patient Case Series
Case series demonstrates peel-and-place NPWT dressing enables 4–7-day wear, faster application, and reliable granulation in lower-leg wounds.
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Clinical Case
Bioactive Glass Matrix for Recalcitrant Trauma and Amputation Wounds
Three lower-extremity trauma cases achieved full closure using boron-based bioactive glass fiber matrix integrated into multimodal wound care.
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Clinical Case
CTPs Equalize Diabetic Wound Outcomes: 138-Patient Real-World Study
Real-world study shows cellular tissue products accelerate diabetic wound healing and eliminate healing disparities when initiated early after week 4.
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Clinical Case
Icelandic Cod Fish Skin Grafts for Complex Surgical Wounds
Prospective case series examining acellular cod fish-skin grafts for nonhealing post-surgical wounds, showing faster closure and reduced pain.
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Clinical Case
GV/MB Foam for Peristomal Atopic Dermatitis: A Case-Based Guide
Case study demonstrates gentian violet/methylene blue foam effectiveness for peristomal atopic dermatitis in an 84-year-old colostomy patient.
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Clinical Case
Pediatric Pyoderma Gangrenosum: Multidisciplinary Care Case
Case study of 16-year-old with scleroderma-related suspected PG managed through Wound Balance framework, achieving healing without amputation.
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Clinical Case
3D Xenograft for Stage 4 Pressure Ulcers: Case Series Outcomes
Two-patient case series evaluating porcine liver-derived 3D acellular xenograft for complex Stage-4 pressure ulcers with significant undermining.
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Clinical Case
Cutaneous SCC in Epidermolysis Bullosa: Closure with Decellularized Bovine Pericardium
Decellularized bovine pericardium scaffold enables single-stage closure of cSCC defects in three RDEB patients without donor-site morbidity.
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Clinical Case
Post-Acute Pressure Injury Care: When to Add dHACM
Clinical case series demonstrates durable closure of year-long pressure injuries using adjunctive dehydrated human amnion chorion membrane in home-based wound care.
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